Wyburn-Mason Syndrome Associated With Cutaneous Reactive Angiomatosis and Central Retinal Vein Occlusion.

Abstract

Retinal venous occlusive events are a rare complication of arteriovenous malformations of the retina found in Wyburn-Mason syndrome. The authors present a case of a 28-year-old man diagnosed with Wyburn-Mason syndrome and cutaneous reactive angiomatosis, a reactive angioproliferative disorder induced by vascular occlusion. He developed a central retinal vein occlusion complicated by macular edema and received treatment with intravitreal bevacizumab, which led to resolution of the edema. To the best of the authors' knowledge, this is the first report of an anti- vascular endothelial growth factor agent employed as an effective treatment for macular edema in the setting of Wyburn-Mason syndrome. The association between Wyburn-Mason syndrome and cutaneous reactive angiomatosis is also a novel finding.

• Authors: Alison B Callahan, Dimitra Skondra, Magdalena Krzystolik, Yoshihiro Yonekawa, Dean Eliott
• Journal: Ophthalmic surgery, lasers & imaging retina (Ophthalmic Surg Lasers Imaging Retina) 2015 Jul-Aug Vol. 46 Issue 7 Pg. 760-2 ISSN: 2325-8179 [Electronic] United States
• PMID: 26247458 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2015, SLACK Incorporated.

Chemical References

• Angiogenesis Inhibitors
• VEGFA protein, human
• Vascular Endothelial Growth Factor A
• Bevacizumab

Topics

• Adult
• Angiogenesis Inhibitors (therapeutic use)
• Angiomatosis (diagnosis, drug therapy, etiology)
• Arteriovenous Fistula (complications, diagnosis)
• Bevacizumab (therapeutic use)
• Fluorescein Angiography
• Humans
• Intravitreal Injections
• Macular Edema (diagnosis, drug therapy, etiology)
• Male
• Neurocutaneous Syndromes (complications, diagnosis)
• Retinal Vein Occlusion (diagnosis, drug therapy, etiology)
• Skin Diseases (diagnosis, drug therapy, etiology)
• Tomography, Optical Coherence
• Vascular Endothelial Growth Factor A (antagonists & inhibitors)
• Visual Acuity (physiology)