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A New Hydroxy Metabolite of 2-Oxoglutarate Regulates Metabolism in Hypoxia.

Abstract
Two articles in this issue (Intlekofer et al., 2015; Oldham et al., 2015) show a new metabolic pathway regulated by hypoxia, but independently of HIF1 or HIF2. L-2-hydroxyglutarate, produced in hypoxia by malate dehydrogenases and LDHA, is a potent inhibitor of KDM4C, and through redox stress reduces glycolysis.
AuthorsAdrian L Harris
JournalCell metabolism (Cell Metab) Vol. 22 Issue 2 Pg. 198-200 (Aug 04 2015) ISSN: 1932-7420 [Electronic] United States
PMID26244928 (Publication Type: Journal Article)
CopyrightCopyright © 2015 Elsevier Inc. All rights reserved.

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