Abstract |
Two articles in this issue (Intlekofer et al., 2015; Oldham et al., 2015) show a new metabolic pathway regulated by hypoxia, but independently of HIF1 or HIF2. L-2-hydroxyglutarate, produced in hypoxia by malate dehydrogenases and LDHA, is a potent inhibitor of KDM4C, and through redox stress reduces glycolysis.
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Authors | Adrian L Harris |
Journal | Cell metabolism
(Cell Metab)
Vol. 22
Issue 2
Pg. 198-200
(Aug 04 2015)
ISSN: 1932-7420 [Electronic] United States |
PMID | 26244928
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |