[Effectiveness of perioperative preventive use of antibiotics with metronidazole or doxycycline in vaginal hysterectomy].

Abstract

To prove the effectiveness of perioperative antibiotics prophylaxis (PABP) in prevention of postoperative infections after vaginal hysterectomy the efficacy of rectale Metronidazole application (5 times 500 mg; n = 192) was compared with that of Doxycyclin (2 times 200 mg intravenously; n = 116). The infectious morbidity after both prophylactic antibiotic regimes was compared to that of an untreated group (n = 186). In spite of additionally colporrhapies the feverish standard morbidity without prophylaxis was 13.4%, after Metronidazole application 13.5% and after Doxycyclin 2.6% (p less than 0.05). Simultaneously the rate of necessary antibiotic treatment decreased significantly. Pelvic infections complicated 16.7% of vaginal hysterectomies having no prophylaxis, but only 4.3% after Doxycyclin medication (p less than 0.05). Postoperative urinary tract infections (UTI)--mostly asymptomatic bacteriuria--were not influenced by any PABP. Whereas UTI after bladder catheter duration shorter than two days occurred in 26.0% (without PABP), 29.9% (Metronidazole) respectively 18.2% (Doxycyclin; p greater than 0.05), the rates after a longer stay were 69.6%, 76.8% and 65.7%. It is concluded, that the febrile standard morbidity and pelvic infections were reduced as well as the rate of necessary antibiotics therapies by a prophylactic application of Doxycyclin, but not with Metronidazole. The incidence of postoperative UTI was not reduced by prophylaxis.

• Authors: B Gerber, H Wilken
• Journal: Zentralblatt fur Gynakologie (Zentralbl Gynakol) Vol. 111 Issue 23 Pg. 1542-8 ( 1989) ISSN: 0044-4197 [Print] Germany
• Vernacular Title: Effektivität der perioperativen Antibiotikaprophylaxe mit Metronidazol oder Doxycyclin bei der vaginalen Hysterektomie.
• PMID: 2624006 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Metronidazole
• Doxycycline

Topics

• Administration, Rectal
• Bacteriuria (prevention & control)
• Doxycycline (administration & dosage)
• Drug Administration Schedule
• Female
• Humans
• Hysterectomy
• Hysterectomy, Vaginal
• Infusions, Intravenous
• Metronidazole (administration & dosage)
• Premedication
• Surgical Wound Infection (prevention & control)