Activation of Toll-like receptor 7 inhibits the proliferation and migration, and induces the apoptosis of pancreatic cancer cells.

Abstract	Pancreatic cancer is one of the most malignant types of tumor and has a poor prognosis. Toll‑like receptor 7 (TLR7) has been found to be present and have different roles in different types of cancer cells. In the present study, the roles of TLR7 in BxPC‑3 cells, a human pancreatic adenocarcinoma cell line, were investigated. The cells were treated with gardiquimod, an agonist of TLR7, following which the properties of the cells, including proliferation, migration, cell cycle and apoptosis, were analyzed. It was revealed that activation of TLR7 by gardiquimod inhibited cell proliferation and migration, and induced apoptosis of the cells. In addition, gardiquimod downregulated the expression levels of cyclin B1, cyclin E and B‑cell lymphoma 2, while upregulating the expression of B‑cell‑associated X protein. These results suggested that the activation of TLR7 suppresses the progression of pancreatic cancer.
Authors	Bing-Bing Zou, Fang Wang, Lei Li, Feng-Wei Cheng, Rui Jin, Xin Luo, Li-Xin Zhu, Xiaoping Geng, Sheng-Quan Zhang
Journal	Molecular medicine reports (Mol Med Rep) Vol. 12 Issue 4 Pg. 6079-85 (Oct 2015) ISSN: 1791-3004 [Electronic] Greece
PMID	26238718 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Aminoquinolines BAX protein, human CCNE1 protein, human CTNNB1 protein, human Cyclin E Imidazoles Oncogene Proteins TLR7 protein, human Toll-Like Receptor 7 bcl-2-Associated X Protein beta Catenin gardiquimod
Topics	Aminoquinolines (pharmacology) Apoptosis (drug effects) B-Lymphocytes (metabolism) Cell Line, Tumor Cell Movement (drug effects) Cell Proliferation (drug effects) Cyclin E (genetics, metabolism) Dose-Response Relationship, Drug Down-Regulation Humans Imidazoles (pharmacology) Oncogene Proteins (genetics, metabolism) Pancreatic Neoplasms (pathology) Toll-Like Receptor 7 (agonists, genetics, metabolism) Up-Regulation bcl-2-Associated X Protein (genetics, metabolism) beta Catenin (genetics, metabolism)

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