Abstract | OBJECTIVE: METHODS: Sixty-six patients with AD, whose Mini-Mental State Examination (MMSE) score were from 10-24, were randomized equally into an intervention group and a control group. The control group was given Aricept (5 mg, once daily). The intervention group was further divided into Yang-Qi deficiency (n = 18) and of Yin-Qi deficiency (n = 15) subgroups. Patients in the Yang-Qi deficiency group were intravenously administered shenfu injection, 60 mL, and deproteinized calf blood injection (DCBI), 1.2 g, once daily. The Yin-Qi deficiency group was given shenmai injection, 60 mL, and DCBI, 1.2 g, once daily. Each course lasted 21 days. RESULTS: Compared with the control group and with pre-treatment in the same group, MMSE, clinical dementia rating, and activities of daily living scale scores in the intervention group were significantly improved (all P < 0.05). These metrics mildly improved in the control group compared with before treatment (P > 0.05). No adverse effects were observed in any group during treatment. CONCLUSION: We found that combined TCM therapy is effective and safe for managing mild to moderate AD.
|
Authors | Songlin Chen, Xiaoli Yao, Yinying Liang, Weiyi Mei, Xiaoyun Liu, Changran Zhang |
Journal | Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
(J Tradit Chin Med)
Vol. 35
Issue 3
Pg. 255-9
(Jun 2015)
ISSN: 0255-2922 [Print] China |
PMID | 26237827
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Aged
- Aged, 80 and over
- Alzheimer Disease
(drug therapy)
- Bone Marrow
(drug effects)
- Drugs, Chinese Herbal
(administration & dosage)
- Female
- Humans
- Male
- Middle Aged
- Qi
- Yang Deficiency
(drug therapy)
- Yin Deficiency
(drug therapy)
|