Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients.

Abstract

The prospective study included 54 asymptomatic high-risk patients who underwent coronary CT angiography (CTA) and regadenoson-induced stress CT perfusion (rsCTP). Diagnostic accuracy of significant stenosis (≥50%) determination was evaluated for CTA alone and CTA + rsCTP in 27 patients referred to ICA due to the positive rsCTP findings. Combined evaluation of CTA + rsCTP had higher diagnostic accuracy over CTA alone (per-segment: specificity 96 versus 68%, p = 0.002; per-vessel: specificity 95 versus 75%, p = 0.012) and high overruling rate of rsCTP was proved in intermediate stenosis (40-70%). Results demonstrate a significant additional value of rsCTP in the assessment of intermediate coronary artery stenosis found with CTA.

• Authors: Jan Baxa, Milan Hromádka, Jakub Šedivý, Lucie Štěpánková, Jiří Moláček, Bernhard Schmidt, Thomas Flohr, Jiří Ferda
• Journal: BioMed research international (Biomed Res Int) Vol. 2015 Pg. 105629 ( 2015) ISSN: 2314-6141 [Electronic] United States
• PMID: 26236712 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Purines
• Pyrazoles
• regadenoson

Topics

• Blood Pressure
• Coronary Angiography
• Coronary Stenosis (diagnostic imaging, physiopathology)
• Female
• Heart Rate
• Humans
• Male
• Middle Aged
• Myocardial Perfusion Imaging
• Purines (pharmacology)
• Pyrazoles (pharmacology)
• Tomography, X-Ray Computed