Self-Assembled Nanoparticles Based on Amphiphilic Anticancer Drug-Phospholipid Complex for Targeted Drug Delivery and Intracellular Dual-Controlled Release.

Abstract	Integrating advantages of mitomycin C (MMC)-phospholipid complex for increased drug encapsulation efficiency and reduced premature drug release, DSPE-PEG-folate (DSPE-PEG-FA) for specific tumor targeting, we reported a simple one-pot self-assembly route to prepare the MMC-phospholipid complex-loaded DSPE-PEG-based nanoparticles (MP-PEG-FA NPs). Both confocal imaging and flow cytometry demonstrated that MMC was distributed into nuclei after cellular uptake and intracellular drug delivery. More importantly, the systemically administered MP-PEG-FA NPs led to increased blood persistence and enhanced tumor accumulation in HeLa tumor-bearing nude mice. This study introduces a simple and effective strategy to design the anticancer drug-phospholipid complex-based targeted drug delivery system for sustained/controlled drug release.
Authors	Yang Li, Jinyan Lin, Xiangrui Yang, Yanxiu Li, Shichao Wu, Yu Huang, Shefang Ye, Liya Xie, Lizong Dai, Zhenqing Hou
Journal	ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 7 Issue 32 Pg. 17573-81 (Aug 19 2015) ISSN: 1944-8252 [Electronic] United States
PMID	26234408 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antineoplastic Agents Drug Carriers Phospholipids poly(ethylene glycol)-folate Polyethylene Glycols Mitomycin Folic Acid
Topics	Animals Antineoplastic Agents (administration & dosage, chemistry, pharmacokinetics) Cell Survival (drug effects) Drug Carriers (chemistry, metabolism, toxicity) Drug Liberation Female Folic Acid (analogs & derivatives, chemistry) Half-Life HeLa Cells Humans Mice Mice, Nude Microscopy, Confocal Mitomycin (administration & dosage, chemistry, pharmacokinetics) Nanoparticles (chemistry) Phospholipids (chemistry) Polyethylene Glycols (chemistry) Rats Tissue Distribution Transplantation, Heterologous Uterine Cervical Neoplasms (drug therapy)

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