Hepatocellular Carcinoma in a Patient with Polycystic Liver Disease.

Abstract

A 49-year-old Japanese woman with polycystic liver disease (PLD) was admitted for right hypochondrial pain. CT showed a huge enhancing mass in the liver. She tested negative for other liver diseases, such as hepatitis B and C and alcoholic liver disease. After the patient expired due to hepatic failure, an autopsy revealed poorly differentiated hepatocellular carcinoma (HCC) surrounded by multiple hepatic cysts. The small amount of residual hepatic parenchyma showed nonalcoholic fatty liver disease (NAFLD) with severe steatosis. Severe emaciation was also apparent. This case suggests that malnutrition in patients with symptomatic PLD may contribute to the development of HCC via NAFLD.

• Authors: Masahiro Kawada, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Keiichi Sumida, Koki Mise, Satoshi Hamanoue, Masayuki Yamanouchi, Naoki Sawa, Kenmei Takaichi, Takeshi Fujii, Yoshifumi Ubara
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 54 Issue 15 Pg. 1891-6 ( 2015) ISSN: 1349-7235 [Electronic] Japan
• PMID: 26234231 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Autopsy
• Carcinoma, Hepatocellular (pathology)
• Cysts (pathology)
• Fatal Outcome
• Female
• Humans
• Liver Diseases (pathology)
• Liver Neoplasms (pathology)
• Malnutrition (complications, pathology)
• Middle Aged