[Chemical constituents from Morus notabilis and their cytotoxic effect].

Abstract

Une new flavonoids named as notabilisin K (1), together with four known compounds, morusin (2), mulberrofuran A (3), neocyclomorusin (4) and mornigrol F (5) are separated from 95% ethanol extracts of the twigs of Morus notabilis. Compounds 2-5 are separated from this plant for the first time. Notabilisin I, notabilisin J exhibits certain effect against cells of HCT-116, HepG2 and A2780 with IC50 values ranging from 1.47 μmol x L(-1) to 5.46 μmol x L(-1). Morusin exhibits strong effect against five kinds of human cancer cells (BGC823, A2780, HCT-116, HepG2 and NCI-H1650) with IC50 values ranging from 0.74 μmol x L(-1) to 1.58 μmol x L(-1).

• Authors: Pan Zhen, Gang Ni, Xiao-guang Chen, Ruo-yun Chen, Han-ze Yang, De-quan Yu
• Journal: Yao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 50 Issue 5 Pg. 579-82 (May 2015) ISSN: 0513-4870 [Print] China
• PMID: 26234140 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Benzofurans
• Flavonoids
• Plant Extracts
• Terpenes
• morusin

Topics

• Antineoplastic Agents, Phytogenic (chemistry)
• Benzofurans (chemistry)
• Flavonoids (chemistry)
• Hep G2 Cells
• Humans
• Inhibitory Concentration 50
• Morus (chemistry)
• Plant Extracts (chemistry)
• Terpenes (chemistry)