[Role of Bradikynin in the Mechanism of Ischemic Preconditioning of the Heart. Prospects of Bradykinin Application in Cardiosurgical Praxis].

Abstract

Bradykinin level is increased in myocardium in response to short-term ischemia/reperfusion that is one of the evidences of its trigger role in ischemic preconditioning (IP). Pharmacological induced increase of endogenous bradykinin and kallidin-like peptide levels in myocardium enhances cardiac tolerance to impact of ischemia/reperfusion. Experiments with genetically modified mice indicate that kinins are involved in preconditioning but they are not the only trigger of IP. The B2-receptor blocking abolishes antiarrhythmic, infarct reducing effects ofpreconditioning, eliminates IP-induced cardiac tolerance to oxidative stress. Exogenous bradykinin mimics inotropic and cardioprotective effects of IP but does not mimic antiarrhythmic effect of preconditioning. The intracoronary or intravenous bradykinin infusion enhances human heart resistance to ischemia/reperfusion. Implementation of the cardioprotective effect of IP is provided by the activation of multiple signaling pathways that involve: B2-receptor, calcitonin gene-related peptide, NO-synthase, guanylyl cyclase, cGMP, protein kinase G, mitochondrial KATP channels, reactive oxygen species, kinases C, ERK andAkt. To increase of the human heart tolerance to ischemia/reperfusion is necessary to develop B2-receptor agonists devoid hypotensive and pro-inflammatory properties.

• Authors: L N Maslov, N V Naryzhnaia, Iu K Podoksenov, A S Gorbunov, Y Zhang, J-M Pei
• Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk (Vestn Ross Akad Med Nauk) Issue 2 Pg. 188-95 ( 2015) ISSN: 0869-6047 [Print] Russia (Federation)
• PMID: 26234091 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Vasodilator Agents
• Bradykinin

Topics

• Animals
• Bradykinin (pharmacokinetics)
• Cardiac Surgical Procedures (methods)
• Humans
• Intraoperative Period
• Ischemic Preconditioning (methods)
• Myocardial Ischemia (metabolism, therapy)
• Myocardium (metabolism)
• Oxidative Stress
• Vasodilator Agents (pharmacokinetics)