Abstract | BACKGROUND: METHODS: From participants of the Suita study without a history of cardiovascular diseases, a total of 2502 subjects (805 men, median age 64 years) who underwent carotid ultrasonography were enrolled. Subjects were divided into current smokers (n = 566) and never-smokers. Ex-smokers were not included in the study. Each group was subdivided according to the median levels of markers (plasma fibrinogen [2.99 g/L] and hsCRP [.51 mg/L]) and the smoking amounts. We compare the adjusted maximum and mean intima-media thickness (IMT). RESULTS: In men and women, maximum IMT and mean IMT of the high fibrinogen and high hsCRP (Fib(H)CRP(H)) with smoking were thicker than those of the low fibrinogen and low hsCRP (Fib(L)CRP(L)) without smoking, the Fib(L)CRP(L) with smoking, and the Fib(H)CRP(H) without smoking after adjusting for covariates. The Fib(L)CRP(L) with smoking had thicker IMTs than the Fib(L)CRP(L) without smoking. There was a dose-dependent smoking effect on IMT in men. These trends were similar in age 60, 65, and 70. CONCLUSIONS:
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Authors | Kayoko Kawase Ishihara, Yoshihiro Kokubo, Chiaki Yokota, Eisuke Hida, Toshiyuki Miyata, Kazunori Toyoda, Masayasu Matsumoto, Kazuo Minematsu, Yoshihiro Miyamoto |
Journal | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
(J Stroke Cerebrovasc Dis)
Vol. 24
Issue 10
Pg. 2385-9
(Oct 2015)
ISSN: 1532-8511 [Electronic] United States |
PMID | 26232890
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Fibrinogen
- C-Reactive Protein
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Topics |
- Aged
- C-Reactive Protein
(metabolism)
- Carotid Arteries
(diagnostic imaging)
- Carotid Artery Diseases
(blood, epidemiology)
- Female
- Fibrinogen
(metabolism)
- Humans
- Japan
- Male
- Middle Aged
- Smoking
(adverse effects, blood, epidemiology)
- Ultrasonography
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