Abstract | OBJECTIVE: MATERIALS AND METHODS: Between 1979 and 2010, 23 patients with clinical stage (CS) I and II disease underwent primary RPLND at our institution with teratoma only in the retroperitoneum. No patient received adjuvant chemotherapy and the minimum follow-up was 2 years. RESULTS: At the initial diagnosis, 13 patients (56.5%) had CS I disease and 10 patients (43.5%) had CS II disease. Pathologic staging demonstrated IIA in 13 patients (56.5%), IIB in 8 patients (34.8%), and IIC in 2 patients (8.7%). The 5-year disease-free survival (DFS) was 100% with a median follow-up of 5.8 years (range, 2.1-25.4). DFS was not significantly different comparing pathologic stage IIA vs IIB/IIC disease (P = .73). Two patients (14%) developed late relapses. One patient had a pelvic recurrence 11 years after primary RPLND. Final pathology from the pelvic resection demonstrated embryonal carcinoma. He remains disease free after his second surgery. The second patient had a contralateral retroperitoneal recurrence with yolk-sac tumor and teratoma 11 years after primary RPLND. He was treated with chemotherapy followed by postchemotherapy RPLND. CONCLUSION: The relapse rate for patients with teratoma only at primary RPLND is low irrespective of PS. Adjuvant chemotherapy is therefore not recommended in the management of these patients.
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Authors | Nick W Liu, Clint Cary, Andrew C Strine, Stephen D W Beck, Timothy A Masterson, Richard Bihrle, Richard S Foster |
Journal | Urology
(Urology)
Vol. 86
Issue 5
Pg. 981-4
(Nov 2015)
ISSN: 1527-9995 [Electronic] United States |
PMID | 26232690
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Topics |
- Adolescent
- Adult
- Age Factors
- Databases, Factual
- Disease-Free Survival
- Follow-Up Studies
- Humans
- Kaplan-Meier Estimate
- Lymph Node Excision
(methods)
- Lymph Nodes
(pathology, surgery)
- Male
- Neoplasm Invasiveness
(pathology)
- Neoplasm Recurrence, Local
(drug therapy, epidemiology, pathology)
- Neoplasm Staging
- Retroperitoneal Space
(surgery)
- Retrospective Studies
- Risk Assessment
- Statistics, Nonparametric
- Survival Rate
- Teratoma
(mortality, pathology, surgery)
- Testicular Neoplasms
(mortality, pathology, surgery)
- Treatment Outcome
- Young Adult
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