CML in pregnancy: A case report using leukapheresis and literature review.

Abstract

Chronic myelogenous leukemia (CML) complicating pregnancy is uncommon. Literature search demonstrates only a few case reports and some case series but large studies are lacking due to its uncommon presentation. Management of these patients is particularly challenging due to limited available options as several chemotherapy drugs could potentially lead to adverse outcomes and fetal malformations. Leukapheresis has been used in these situations; however paucity of data exists regarding the outcome and complications associated with the procedure. Using leukapheresis alone for extended period to manage CML during pregnancy is also rare. Here we report a case of CML complicating pregnancy which was successfully managed utilizing leukapheresis, followed by a review of literature addressing this controversial issue.

• Authors: Mahender Yellu, Sue Pinkard, Abhimanyu Ghose, Stephen Medlin
• Journal: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis (Transfus Apher Sci) Vol. 53 Issue 3 Pg. 289-92 (Dec 2015) ISSN: 1473-0502 [Print] England
• PMID: 26231323 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Topics

• Adult
• Female
• Humans
• Leukapheresis (methods)
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive (therapy)
• Pregnancy
• Pregnancy Complications, Hematologic (therapy)
• Pregnancy Complications, Neoplastic (therapy)