Abstract | BACKGROUND: Sickle cell anaemia (SCA) remains associated with high risks of morbidity and early death. Children with SCA are at high risk for ischaemic stroke and transient ischaemic attacks, secondary to intracranial arteriopathy involving carotid and cerebral arteries. Allogeneic haematopoietic stem cell transplantation (HSCT) is the only curative treatment for SCA. We report our experience with transplantation in a group of patients with the Black African variant of SCA. PATIENTS AND METHODS: RESULTS: CONCLUSION: The protocols used for the preparation to the transplant in thalassaemia are very effective also in the other severe haemoglobinopathy as in the sickle cell anaemia with 90% disease free survival. Today, if a SCA patient has a HLA identical family member, the cellular gene therapy through the transplantation of the allogeneic haemopoietic cell should be performed. Tomorrow, hopefully, the autologous genetically corrected stem cell will break down the wall of the immunological incompatibility.
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Authors | Antonella Isgrò, Katia Paciaroni, Javid Gaziev, Pietro Sodani, Cristiano Gallucci, Marco Marziali, Gioia De Angelis, Cecilia Alfieri, Michela Ribersani, Andrea Roveda, Olufemi O Akinyanju, T Thompson Wakama, Festus Olusola Olowoselu, Adewumi Adediran, Guido Lucarelli |
Journal | Nigerian medical journal : journal of the Nigeria Medical Association
(Niger Med J)
2015 May-Jun
Vol. 56
Issue 3
Pg. 175-9
ISSN: 0300-1652 [Print] Nigeria |
PMID | 26229224
(Publication Type: Journal Article)
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