Myeloid sarcoma of the skin in a patient with myelodysplastic syndrome.

Abstract

We report the case of a 76-year-old woman who presented with asymptomatic extensive erythematous. Firm plaques were noted over the right cheek. Complete blood count was normal, as was a peripheral smear. An excision biopsy taken from the cheek showed infiltration of the dermis and hypodermis with atypical cells which were strongly positive for human leukocyte antigen (HLA-DR) and lysozyme and were moderately myeloperoxidase (MPO) enzyme. The results of immunohistochemical staining for CD34, CD117, CD3, CD4, CD8, CD20, CD23, CD56, and ALK-1 were negative. Bone marrow analysis indicated myelodysplastic syndrome RAEB 1 while cytogenetic finding showed tetrasomy 8. It was recommended that the patient undergo local radiotherapy of skin lesions, but she refused and was lost to follow-up.

• Authors: Darko Antic, Andrija Bogdanovic, Maja Perunicic Jovanovic, Jelica Jovanovic, Ivo Elezovic
• Journal: Acta dermatovenerologica Croatica : ADC (Acta Dermatovenerol Croat) Vol. 23 Issue 2 Pg. 134-7 ( 2015) ISSN: 1847-6538 [Electronic] Croatia
• PMID: 26228825 (Publication Type: Case Reports, Journal Article)

Topics

• Aged
• Biopsy, Needle
• Female
• Humans
• Immunohistochemistry
• Myelodysplastic Syndromes (complications, pathology, physiopathology)
• Neoplasm Invasiveness (pathology)
• Neoplasm Staging
• Prognosis
• Risk Assessment
• Sarcoma, Myeloid (complications, pathology, physiopathology)