Abstract | INTRODUCTION: AIM: PATIENTS AND METHODS: RESULTS: Total and free platinum concentrations in the plasma were measured at each of the time points, and the area under the curve (AUC, measured in units of µg h/ml) was calculated based on the platinum concentration with the following formula: CL (clearance of free platinum: l/h) = 0.042 × CCr (ml/min) + 5.84. The response rate was 70.1 % (in CR 51 %, in PR 19 %). Histological CR was seen in 28.6 % of surgical specimens. Moderate hematological side effects were seen. However, severe adverse events were not observed, including those associated with cannulation of the femoral artery. CONCLUSION: The dose-clearance formula that was established by our study can most likely be utilized to accurately predict the optimal administered dose of nedaplatin for arterial infusion chemotherapy.
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Authors | Minoru Miyake, Yumiko Ohbayashi, Akinori Iwasaki, Fumi Sawai, Yoshihiro Toyama, Yoshihiro Nishiyama |
Journal | Journal of maxillofacial and oral surgery
(J Maxillofac Oral Surg)
Vol. 14
Issue 3
Pg. 616-23
(Sep 2015)
ISSN: 0972-8279 [Print] India |
PMID | 26225053
(Publication Type: Journal Article)
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