Imaging Tumor Acidity: pH-Low Insertion Peptide Probe for Optoacoustic Tomography.

Abstract

Optoacoustic tomography has been used for the detection of pancreatic ductal adenocarcinoma targeted by pH-low insertion peptide (pHLIP) conjugated to near-infrared fluorescent dye. It was proved that tumor targeting is pH dependent. The approach could have major implication for detection and monitoring of pancreatic and other cancers.

• Authors: Yana K Reshetnyak
• Journal: Clinical cancer research : an official journal of the American Association for Cancer Research (Clin Cancer Res) Vol. 21 Issue 20 Pg. 4502-4 (Oct 15 2015) ISSN: 1557-3265 [Electronic] United States
• PMID: 26224874 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Comment)
• Copyright: ©2015 American Association for Cancer Research.

Chemical References

• Membrane Proteins

Topics

• Adenocarcinoma (diagnosis, metabolism)
• Animals
• Female
• Humans
• Membrane Proteins (metabolism)
• Pancreatic Neoplasms (diagnosis, metabolism)