Baclofen Induced Encephalopathy in a 6-Year-Old Boy with Advanced Renal Failure.

Abstract

Baclofen is a drug for many diseases for all ages, but it is hazardous in patients with renal failure. This article talks about a case of baclofen overdose in a child with renal failure. A 6-year-old boy admitted to the emergency department with a loss of consciousness, hypotonia, and areflexia following administration of 20 mg baclofen (1mg/kg/daily) in total dose for his voiding dysfunction. His laboratory tests showed advanced renal failure. After withholding the medication and supportive therapy, he recovered completely after two days. After arousal, he complained of insomnia, strange sensations on the skin, intentional tremors, and ataxia. He left the hospital in good condition in three days. Renal function control before baclofen administration is mandatory especially in high-risk groups. A total dose of 1mg/kg lead to encephalopathy in children with advanced renal failure, with subtle persistent complaints persist are often overlooked for a while.

• Authors: Majid Malak, Mohammad Barzegar
• Journal: Iranian journal of child neurology (Iran J Child Neurol) Vol. 9 Issue 2 Pg. 61-3 ( 2015) ISSN: 1735-4668 [Print] Iran
• PMID: 26221166 (Publication Type: Case Reports)