Abstract | BACKGROUND: OBJECTIVE: METHODS: Adults with PAH were enrolled in this bilaterally paired single-subject study. Each patient was randomly treated with 1,500 U rimabotulinumtoxinB on 1 axilla and 50 U onabotulinumtoxinA contralaterally. Hyperhidrosis Disease Severity Scale was assessed before and after treatment up to 20 weeks. A 10-cm visual analog scale representing improvement of hidrotic symptom and starch- iodine test were also used to assess therapeutic efficacy. RESULTS: Twenty-four patients completed the study. Both groups showed comparable and efficacious anhidrotic effects through 20 weeks for any variable. There were no significant differences in terms of the onset of action or mean duration of action between the 2 groups. Overall satisfaction with the treatment was equally high in both groups. CONCLUSION: Both toxins showed comparable anhidrotic effect for the treatment of axillary hyperhidrosis at a conversion ratio of 1:30.
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Authors | Jee Soo An, Chong Hyun Won, Ji Si Han, Hyun Sun Park, Kyle K Seo |
Journal | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
(Dermatol Surg)
Vol. 41
Issue 8
Pg. 960-7
(Aug 2015)
ISSN: 1524-4725 [Electronic] United States |
PMID | 26218729
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Acetylcholine Release Inhibitors
- rimabotulinumtoxinB
- Botulinum Toxins, Type A
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Topics |
- Acetylcholine Release Inhibitors
(adverse effects, therapeutic use)
- Adult
- Axilla
- Botulinum Toxins, Type A
(adverse effects, therapeutic use)
- Double-Blind Method
- Female
- Humans
- Hyperhidrosis
(drug therapy)
- Male
- Middle Aged
- Patient Satisfaction
- Prospective Studies
- Severity of Illness Index
- Time Factors
- Treatment Outcome
- Visual Analog Scale
- Young Adult
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