Elevated levels of Th17 cells in children with central obesity.

Abstract

BACKGROUND:

It is believed that the recently discovered interleukin 17-producing Th17 cells play a role in the pathogenesis of chronic inflammation in the course of obesity and diabetes.

OBJECTIVES:

The purpose of our study was to complete data on this subject in children.

METHODS:

We assessed Th17 cell levels in the peripheral blood of children diagnosed with central obesity (n = 14) and compared the results with data obtained in patients with newly diagnosed (n = 11) and long-term type 1 diabetes mellitus (n = 18), and in a control group as well (n = 24).

RESULTS:

(i) Children with central obesity were characterized by higher percentages of Th17 cells as compared to children from the control group; (ii) in the peripheral blood of patients with long-term type 1 diabetes the Th17 cell counts were higher compared to the control group; (iii) total plasma cholesterol concentration correlated positively with Th17/Treg cells ratio; and (iv) among patients with long-term diabetes, disease duration correlated positively with Th17 cell count and Th17/Th1 cell ratio.

CONCLUSION:

The results of our study indicate that Th17 cells may be involved in chronic inflammation accompanying obesity and type 1 diabetes mellitus in children.

• Authors: Włodzimierz Łuczyński, Kamil Grubczak, Marcin Moniuszko, Barbara Głowińska-Olszewska, Artur Bossowski
• Journal: Scandinavian journal of clinical and laboratory investigation (Scand J Clin Lab Invest) Vol. 75 Issue 7 Pg. 595-601 (Nov 2015) ISSN: 1502-7686 [Electronic] England
• PMID: 26216210 (Publication Type: Journal Article)

Chemical References

• Cholesterol

Topics

• Adolescent
• Child
• Cholesterol (blood)
• Diabetes Mellitus, Type 1 (blood, immunology, pathology)
• Female
• Humans
• Inflammation
• Male
• Pediatric Obesity (blood, immunology, pathology)
• Th17 Cells (immunology)