Hematopoietic pre-B cell leukemia transcription factor interacting protein is overexpressed in gastric cancer and promotes gastric cancer cell proliferation, migration, and invasion.

Abstract

Hematopoietic pre-B cell leukemia transcription factor interacting protein (HPIP) has been shown to play an important role in the development and progression of some cancers. However, the role of HPIP in gastric cancer (GC) is unclear. Here, we show that HPIP is upregulated in most GC patients and promotes GC cell proliferation, migration, and invasion. In GC patients, HPIP positively associates with tumor size and nodal metastasis, and negatively associates with tumor differentiation. Hematopoietic pre-B cell leukemia transcription factor interacting protein increases GC cell proliferation through activation of G1 /S and G2 /M cell cycle transitions, accompanied by a marked increase of the positive cell cycle regulators, including cyclin D1, cyclin A, and cyclin B1. Hematopoietic pre-B cell leukemia transcription factor interacting protein enhances GC cell migration and invasion, and modulates epithelial-mesenchymal transition, which plays a key role in cancer cell migration and invasion. These data underscore the critical role of HPIP in GC cell proliferation and progression and suggest that HPIP inhibition may be a useful therapeutic strategy for GC treatment.

• Authors: Yingying Feng, Ling Li, Xiaomei Zhang, Yunjing Zhang, Yingchun Liang, Jinjing Lv, Zhongyi Fan, Jing Guo, Tian Hong, Beibei Ji, Quanbo Ji, Guohui Mei, Lihua Ding, Shu Zhang, Xiaojie Xu, Qinong Ye
• Journal: Cancer science (Cancer Sci) Vol. 106 Issue 10 Pg. 1313-22 (Oct 2015) ISSN: 1349-7006 [Electronic] England
• PMID: 26211905 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

Chemical References

• CCNA1 protein, human
• CCNB1 protein, human
• CCND1 protein, human
• Cyclin A1
• Cyclin B1
• DNA-Binding Proteins
• Pre-B-Cell Leukemia Transcription Factor 1
• Proto-Oncogene Proteins
• RNA, Small Interfering
• pbx1 protein, human
• Cyclin D1

Topics

• Cell Line, Tumor
• Cell Movement (genetics)
• Cell Proliferation (genetics)
• Cyclin A1 (biosynthesis)
• Cyclin B1 (biosynthesis)
• Cyclin D1 (biosynthesis)
• DNA-Binding Proteins (biosynthesis, genetics, metabolism)
• Epithelial-Mesenchymal Transition (genetics)
• Female
• G1 Phase Cell Cycle Checkpoints (genetics)
• G2 Phase Cell Cycle Checkpoints (genetics)
• Gene Expression Regulation, Neoplastic
• Humans
• Lymphatic Metastasis (pathology)
• Male
• Middle Aged
• Neoplasm Invasiveness (pathology)
• Pre-B-Cell Leukemia Transcription Factor 1
• Proto-Oncogene Proteins (biosynthesis, genetics, metabolism)
• RNA Interference
• RNA, Small Interfering
• Stomach Neoplasms (pathology)