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Altered inhibition in the hippocampal neural networks after spreading depression.

Abstract
Prolonged neuronal depression after spreading depression (SD) is followed by a late cellular and synaptic hyperexcitability. Intra- and extracellular recordings of bioelectrical activities were performed in the rodent hippocampus to investigate the role of γ-aminobutyric acid (GABA)-mediated inhibition in the late hyperexcitable state of SD. The effect of KCl-induced negative DC potential shifts was investigated on extracellularly recorded paired-pulse depression (PPD) and bicuculline-induced afterdischarges as well as intracellularly recorded inhibitory post synaptic potentials (IPSPs) in the hippocampal CA1 area. The results revealed that SD decreased the degree of PPD, enhanced the number and duration of bicuculline-induced afterdischarges, and reduced the amplitude and duration of IPSPs. Application of low concentrations of bicuculline before the induction of SD enhanced the inhibitory effect of SD on IPSPs. Data indicate the contribution of GABA-mediated inhibition to SD-induced delayed hyperexcitability. Modulation of GABA function in the late hyperexcitability phase of SD may play a role in therapeutic management of SD-related neurological disorders.
AuthorsM Mesgari, N Ghaffarian, M Khaleghi Ghadiri, H Sadeghian, E-J Speckmann, W Stummer, A Gorji
JournalNeuroscience (Neuroscience) Vol. 304 Pg. 190-7 (Sep 24 2015) ISSN: 1873-7544 [Electronic] United States
PMID26210578 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
CopyrightCopyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
Chemical References
  • GABA-A Receptor Antagonists
  • gamma-Aminobutyric Acid
  • Potassium Chloride
  • Bicuculline
Topics
  • Animals
  • Bicuculline (pharmacology)
  • CA1 Region, Hippocampal (drug effects, physiology)
  • Cortical Spreading Depression (drug effects, physiology)
  • GABA-A Receptor Antagonists (pharmacology)
  • Inhibitory Postsynaptic Potentials (drug effects, physiology)
  • Male
  • Microelectrodes
  • Neural Inhibition (drug effects, physiology)
  • Neurons (drug effects, physiology)
  • Potassium Chloride
  • Rats, Wistar
  • gamma-Aminobutyric Acid (metabolism)

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