Abstract | BACKGROUND: Little is known about the kinetics of T-cell subsets in lung transplant recipients (LTR) and their association with the occurrence of opportunistic infections (OI). OBJECTIVES: STUDY DESIGN: RESULTS: LTR with a nadir CD4 T-cell count <200 cells/μl had consistently lower CD4 and CD8 T-cell counts than LTR with a nadir CD4 T-cell count >200 cells/μl (p<0.001). In LTR with a nadir CD4 T-cell count <200 cells/μl, the cumulative incidence of viral infections detected in peripheral blood and in bronchoalveolar lavage (BAL) samples was higher than in LTR with a nadir CD4 T-cell count >200 cells/μl (p=0.0012 and p=0.0058, respectively). A nadir CD4 T-cell count <200 cells/μl within the first three months post- transplantation predicted a higher frequency of viral infectious episodes in BAL samples within the subsequent six month period (p=0.0066). CONCLUSIONS: Stratification of patients according to nadir CD4 T-cell count may represent a new and simple approach for early identification of patients at risk for subsequent virus infections.
|
Authors | Sandra A Calarota, Antonella Chiesa, Annalisa De Silvestri, Monica Morosini, Tiberio Oggionni, Piero Marone, Federica Meloni, Fausto Baldanti |
Journal | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
(J Clin Virol)
Vol. 69
Pg. 110-6
(Aug 2015)
ISSN: 1873-5967 [Electronic] Netherlands |
PMID | 26209391
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2015 Elsevier B.V. All rights reserved. |
Topics |
- Adult
- Bronchoalveolar Lavage Fluid
(immunology, virology)
- CD4 Lymphocyte Count
- CD4-Positive T-Lymphocytes
(metabolism)
- CD8-Positive T-Lymphocytes
(metabolism)
- Community-Acquired Infections
(blood, epidemiology, immunology, virology)
- Female
- Humans
- Incidence
- Lung Transplantation
(adverse effects)
- Lymphocyte Count
- Male
- Middle Aged
- Opportunistic Infections
(blood, epidemiology, immunology, virology)
- Predictive Value of Tests
- T-Lymphocyte Subsets
(metabolism)
|