[Evaluation of the efficacy of a new antimycotic molecule for topical use: naftifine].

Abstract

The antifungal efficacy and tolerability of naftifine (cream, gel, 1% solution), were tested in an open, mycologically controlled study in 29 patients (mean age 32.7 +/- 2.8 years; 15 males, 14 females) with dermatomycosis caused by dermatophytes and yeasts. Particularly, 16 patients were affected with Tinea corporis; 11 patients by Pityriasis Versicolor and 2 other by cutaneous candidiasis. The mean treatment period was 32.9 days in a range from 1 to 44 days. Only one patient, with cutaneous candidiasis dropped out on the first day, because of a primary irritative dermatitis. All the remaining patients (96.4%) were recovered, and the severity of clinical symptoms, particularly erythema and itching, showed a very rapid decline. Two weeks after the treatment, a relapse emerged from a fungal growth culture, only in 2 patients (6.8%) affected with Microsporum canis. Local side effects, mostly burning, were recorded in 2 patients (6.8%).

• Authors: G Albanese, P Giorgetti, L Santagostino, R Di Cintio, M D Colombo
• Journal: Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia (G Ital Dermatol Venereol) Vol. 124 Issue 5 Pg. XXXIII-XXXVII (May 1989) ISSN: 0392-0488 [Print] Italy
• Vernacular Title: Valutazione dell'efficacia di una nuova molecola antimicotica per uso topico: la naftifina.
• PMID: 2620916 (Publication Type: English Abstract, Journal Article)

Chemical References

• Amines
• Antifungal Agents
• Gels
• Ointments
• Solutions
• Allylamine
• naftifine

Topics

• Adult
• Allylamine (administration & dosage, analogs & derivatives, therapeutic use)
• Amines (therapeutic use)
• Antifungal Agents (administration & dosage, therapeutic use)
• Dermatomycoses (drug therapy)
• Drug Evaluation
• Female
• Gels
• Humans
• Male
• Ointments
• Solutions