Abstract |
A novel folate- polydiacetylene- liposome (FP-PL) with both targeted drug delivery and fluorescence tracing was prepared by thin film rehydration method. The simulated drug delivery was performed in Bcap-37 breast cancer cells and Hs578Bst normal cells in vitro. The internalization and distribution of FP-PLs in the cells were presented by fluorescence cell imaging. The results show that the FP-PLs possess low cytotoxicity, good biocompatibility and better targeting efficiency in comparison to polydiacetylene- liposomes (P-PLs).
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Authors | Lielie Li, Xueqin An, Xiaojuan Yan |
Journal | Colloids and surfaces. B, Biointerfaces
(Colloids Surf B Biointerfaces)
Vol. 134
Pg. 235-9
(Oct 01 2015)
ISSN: 1873-4367 [Electronic] Netherlands |
PMID | 26208294
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier B.V. All rights reserved. |
Chemical References |
- Liposomes
- Polyacetylene Polymer
- Polymers
- Polyynes
- polydiacetylene
- Folic Acid
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Topics |
- Cell Line, Tumor
- Drug Delivery Systems
- Folic Acid
(chemistry)
- Humans
- Liposomes
- Microscopy, Fluorescence
(methods)
- Polyacetylene Polymer
- Polymers
(chemistry)
- Polyynes
(chemistry)
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