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Folate-polydiacetylene-liposome for tumor targeted drug delivery and fluorescent tracing.

Abstract
A novel folate-polydiacetylene-liposome (FP-PL) with both targeted drug delivery and fluorescence tracing was prepared by thin film rehydration method. The simulated drug delivery was performed in Bcap-37 breast cancer cells and Hs578Bst normal cells in vitro. The internalization and distribution of FP-PLs in the cells were presented by fluorescence cell imaging. The results show that the FP-PLs possess low cytotoxicity, good biocompatibility and better targeting efficiency in comparison to polydiacetylene-liposomes (P-PLs).
AuthorsLielie Li, Xueqin An, Xiaojuan Yan
JournalColloids and surfaces. B, Biointerfaces (Colloids Surf B Biointerfaces) Vol. 134 Pg. 235-9 (Oct 01 2015) ISSN: 1873-4367 [Electronic] Netherlands
PMID26208294 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier B.V. All rights reserved.
Chemical References
  • Liposomes
  • Polyacetylene Polymer
  • Polymers
  • Polyynes
  • polydiacetylene
  • Folic Acid
Topics
  • Cell Line, Tumor
  • Drug Delivery Systems
  • Folic Acid (chemistry)
  • Humans
  • Liposomes
  • Microscopy, Fluorescence (methods)
  • Polyacetylene Polymer
  • Polymers (chemistry)
  • Polyynes (chemistry)

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