[Immunomonitoring for cytomegalovirus infection in kidney transplantation: Development and prospects].

Abstract

Cytomegalovirus infection in kidney transplantation is associated with increased morbidity and mortality through direct and indirect effects. International guidelines had been recently updated, focusing on diagnostic, prevention strategies and curative treatment. Cytomegalovirus-specific immune response plays also an important function in controlling the virus. Here, we propose to present the different components of this specific immune response and the advantages of immune monitoring for patient's management: identification of patients who require a treatment, adaptation of curative treatment length, guidance for resistance genotypic testing.

• Authors: Hannah Kaminski, Lionel Couzi, Julie Déchanet-Merville, Pierre Merville
• Journal: Nephrologie & therapeutique (Nephrol Ther) Vol. 11 Issue 6 Pg. 465-73 (Nov 2015) ISSN: 1872-9177 [Electronic] France
• Vernacular Title: Intérêt de l'immuno-surveillance dans l'infection à cytomégalovirus en transplantation rénale : mise au point et perspectives.
• PMID: 26206770 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2015 Association Société de néphrologie. Published by Elsevier SAS. All rights reserved.

Chemical References

• Antiviral Agents

Topics

• Antiviral Agents (therapeutic use)
• Cytomegalovirus (immunology)
• Cytomegalovirus Infections (diagnosis, drug therapy, immunology)
• Graft Survival
• Humans
• Kidney Transplantation
• Monitoring, Immunologic (methods)
• Risk Factors