Single-dose ciprofloxacin in the treatment of uncomplicated urinary tract infection in women.

Abstract

In a randomised, double-blind trial two single-dose regimens of ciprofloxacin were evaluated for treatment of acute urinary tract infection (UTI) in women. Fifty-three women received 250 mg and 46 750 mg of ciprofloxacin. Seven days after treatment the eradication rate was 81.1% and 82.6% in the low and high dose groups respectively; the clinical cure rate at 28 days was 64.1% and 73.9% respectively. In women with recurrent UTI a significantly better response was found with the high dose regimen (92% versus 68%; p less than 0.001). It is concluded that a single 250 mg dose of ciprofloxacin is effective for treatment in most women with acute UTI, but in women with recurrent infection a 750 mg dose is preferable.

• Authors: R Raz, E Rottensterich, H Hefter, Y Kennes, I Potasman
• Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (Eur J Clin Microbiol Infect Dis) Vol. 8 Issue 12 Pg. 1040-2 (Dec 1989) ISSN: 0934-9723 [Print] Germany
• PMID: 2620672 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Ciprofloxacin

Topics

• Adolescent
• Adult
• Bacterial Infections (drug therapy, microbiology)
• Ciprofloxacin (administration & dosage, therapeutic use)
• Double-Blind Method
• Drug Administration Schedule
• Drug Resistance, Microbial
• Female
• Humans
• Middle Aged
• Random Allocation
• Recurrence
• Time Factors
• Urinary Tract Infections (drug therapy, microbiology)