Abstract | BACKGROUND AND PURPOSE: METHODS: RESULTS: Nonpermanent AF was present in 2072 patients (46% of cohort), of which 339 (16%) had preexisting heart failure. A total of 2484 patients had permanent AF (54% of cohort), with a higher burden of heart failure including 730 patients (29%; P<0.001). Overall, death because of cardiovascular causes occurred in 57 patients and 45 had stroke or systemic embolism (1.4/100 person-years for each). Overall, the adjusted incidence of the composite outcome was higher in patients with permanent AF than in patients with nonpermanent AF. In multivariate analysis, permanency of AF, creatinine, prior cerebrovascular events, and previous coronary disease were independently associated with the primary outcome. The hazard ratio for permanent versus nonpermanent AF was 1.68 (95% confidence interval, 1.08-2.55; P=0.02). The presence of heart failure increased the risk of adverse outcomes in a similar way in both permanent and nonpermanent AF (interaction P value=0.76). CONCLUSIONS: The risk of cardiovascular death, stroke, or systemic embolism is higher in anticoagulated patients with permanent AF than in those with nonpermanent AF, regardless of preexisting heart failure.
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Authors | Keitaro Senoo, Gregory Y H Lip, Deirdre A Lane, Harry R Büller, Dipak Kotecha |
Journal | Stroke
(Stroke)
Vol. 46
Issue 9
Pg. 2523-8
(Sep 2015)
ISSN: 1524-4628 [Electronic] United States |
PMID | 26205373
(Publication Type: Journal Article)
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Copyright | © 2015 American Heart Association, Inc. |
Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Anticoagulants
(therapeutic use)
- Atrial Fibrillation
(epidemiology, mortality)
- Chronic Disease
(epidemiology, mortality)
- Comorbidity
- Embolism
(epidemiology, mortality)
- Female
- Follow-Up Studies
- Heart Failure
(epidemiology, mortality)
- Humans
- Male
- Middle Aged
- Multicenter Studies as Topic
- Prognosis
- Randomized Controlled Trials as Topic
- Risk
- Stroke
(drug therapy, epidemiology, mortality)
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