Recreational phenethylamine poisonings reported to a French poison control center.

Abstract

OBJECTIVES:

Over the last decade, use of phenethylamines has become increasingly prevalent. This study aimed to describe typical aspects of phenethylamine poisoning in order to better inform patient care.

METHODS:

Phenethylamine poisoning cases reported to the Poison Control Center of Angers, France, from January, 2007 to December, 2013 were examined. Clinical findings were examined in 105 patients, including phenethylamine used, symptoms and final outcome. Patients were predominantly male (80%), with mean age 26±8 years.

RESULTS:

MDMA (38%), amphetamine (18%) and methamphetamine (14%) were the most commonly reported. Synthetic cathinones (10%) and the 2C series (7%) were also found. Substances most commonly associated with phenethylamine poisoning were cannabis (27%), ethanol (20%) and cocaine (9%). The most frequently reported symptoms included anxiety and hallucinations (49%), mydriasis and headache (41%), tachycardia (40%) and hypertension (15%). Complications such as seizures (7%), cardiac arrest (5%), toxic myocarditis (1%) and hemorrhagic stroke (1%) were also observed. Of the cases, the Poison Severity Score was: null or low, 66%, moderate, 21%, severe or fatal, 13%. Of the patients, 77% received hospital care and 12.4% were admitted to an intensive care unit. Analytical confirmations were obtained for all severe cases. While 93% of patients recovered, there were 5 deaths and 2 patients presented with neurological sequelae.

CONCLUSIONS:

Phenethylamine poisonings may be severe in young and healthy individuals. Physicians, toxicologists and analysts should be aware of new phenethylamine consumption trends in order to inform management of patient care and to contribute to a more responsive drug policy.

• Authors: Gaël Le Roux, Chloé Bruneau, Bénédicte Lelièvre, Marie Bretaudeau Deguigne, Alain Turcant, Patrick Harry, David Boels
• Journal: Drug and alcohol dependence (Drug Alcohol Depend) Vol. 154 Pg. 46-53 (Sep 01 2015) ISSN: 1879-0046 [Electronic] Ireland
• PMID: 26205314 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Alkaloids
• Phenethylamines
• phenethylamine
• Ethanol
• Methamphetamine
• cathinone
• Amphetamine
• N-Methyl-3,4-methylenedioxyamphetamine

Topics

• Adolescent
• Adult
• Alkaloids (adverse effects)
• Amphetamine (adverse effects)
• Cannabis (adverse effects)
• Child
• Drug Interactions
• Ethanol (adverse effects)
• Female
• France (epidemiology)
• Hospitalization (statistics & numerical data)
• Humans
• Intensive Care Units
• Male
• Methamphetamine (adverse effects)
• Middle Aged
• N-Methyl-3,4-methylenedioxyamphetamine (adverse effects)
• Phenethylamines (poisoning)
• Poison Control Centers
• Prevalence
• Retrospective Studies
• Symptom Assessment
• Young Adult