Abstract | AIM: To prove the presence of EG-VEGF in tumor ovary and to analyze its involvement in the ovarian carcinogenesis, as promoter of angiogenesis, in relationship with the clinicopathological prognostic factors and survival. METHODS: The study group comprises tumor tissue specimens from 50 cases of surgically treated ovarian cancer that were immunohistochemically investigated. A scoring system based on the percentage of positive cells and the intensity of staining was applied for the semiquantitative assessment of EG-VEGF, as negative or positive. Statistics involved χ2 test, and Kaplan-Meier and log-rank test. RESULTS:
EG-VEGF was positive in 35 cases (70%) and negative in 15 cases (30%). Our data confirmed the predominance of EG-VEGF positivity in the serous subiype as compared to endometrioid and clear cell subtypes, and its absence in mucinous subtype. Moreover, we demonstrated that EG-VEGF is overexpressed mainly in high-grade ovarian carcinomas (type II) than in low-grade ones. Significant differences were registered between the EG-VEGF positive or negative expression and tumor stage and histological subtypes, respectively. Survival analysis showed no differences in patient's survival and EG-VEGF positive and negative cases. CONCLUSIONS: The analysis of EG-VEGF expression in ovarian tumors points out the relationship between the enhanced potential for tumor angiogenesis and the tumor aggressivity.
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Authors | Ludmila Lozneanu, Roxana Avădănei, Anca Maria Cîmpean, Simona Eliza Giuşcă, Cornelia Amălinei, Irina-Draga Căruntu |
Journal | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi
(Rev Med Chir Soc Med Nat Iasi)
2015 Apr-Jun
Vol. 119
Issue 2
Pg. 461-5
ISSN: 0048-7848 [Print] Romania |
PMID | 26204653
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Vascular Endothelial Growth Factor, Endocrine-Gland-Derived
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Topics |
- Adult
- Aged
- Biomarkers, Tumor
(metabolism)
- Carcinoma
(metabolism, mortality, pathology, surgery)
- Female
- Humans
- Kaplan-Meier Estimate
- Middle Aged
- Neoplasm Grading
- Neoplasm Staging
- Neovascularization, Pathologic
(metabolism)
- Ovarian Neoplasms
(metabolism, mortality, pathology, surgery)
- Predictive Value of Tests
- Prognosis
- Sensitivity and Specificity
- Vascular Endothelial Growth Factor, Endocrine-Gland-Derived
(biosynthesis)
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