Abstract | BACKGROUND: Patients with non- alcoholic steatohepatitis (NASH) have increased intestinal permeability and small intestine bacterial overgrowth. AIMS: METHODS: RESULTS: Two hundred and sixty-three (29%) subjects had NAFLD. Subjects with NAFLD had slightly higher LBP (P < 0.001) and EndoCab IgG (P = 0.013) levels. EndoCab IgG remained an independent factor associated with intrahepatic triglycerides after adjusting for other metabolic factors. Among 565 subjects without NAFLD at baseline who had repeated assessment at a median interval of 47 months, 78 (13.8%) developed incident NAFLD and they also had higher LBP (P = 0.016). Moreover, LBP was associated with insulin resistance and dyslipidaemia, and modestly increased with the cytokeratin-18 fragment level but not liver stiffness measurement by transient elastography. Although total energy consumption and individual macronutrients were not associated with endotoxemia, current drinkers (mostly <140 g/week) had lower endotoxin, EndoCab IgG and fetuin-A levels than nondrinkers. CONCLUSIONS:
Endotoxin markers are associated with NAFLD in the general population, but do not have a major effect on NASH and fibrosis. People with modest alcohol consumption have lower serum endotoxin. This may partly explain the lower risk of NAFLD and NASH in modest drinkers in previous observational studies.
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Authors | V W-S Wong, G L-H Wong, H-Y Chan, D K-W Yeung, R S-M Chan, A M-L Chim, C K-M Chan, Y-K Tse, J Woo, W C-W Chu, H L-Y Chan |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 42
Issue 6
Pg. 731-40
(Sep 2015)
ISSN: 1365-2036 [Electronic] England |
PMID | 26202818
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 John Wiley & Sons Ltd. |
Chemical References |
- Acute-Phase Proteins
- Biomarkers
- Carrier Proteins
- Immunoglobulin G
- KRT18 protein, human
- Keratin-18
- Membrane Glycoproteins
- lipopolysaccharide-binding protein
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Topics |
- Acute-Phase Proteins
(metabolism)
- Adult
- Alcohol Drinking
(metabolism)
- Biomarkers
- Carrier Proteins
(metabolism)
- Diet
- Dyslipidemias
(metabolism)
- Endotoxemia
(epidemiology, physiopathology)
- Female
- Fibrosis
- Humans
- Immunoglobulin G
(metabolism)
- Insulin Resistance
(physiology)
- Intestines
(microbiology)
- Keratin-18
(metabolism)
- Male
- Membrane Glycoproteins
(metabolism)
- Middle Aged
- Molecular Sequence Data
- Non-alcoholic Fatty Liver Disease
(epidemiology, physiopathology)
- Prospective Studies
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