Bimatoprost 0.01 % for previously treated patients with open-angle glaucoma or ocular hypertension in the Korean clinical setting.

Abstract

PURPOSE:

To evaluate the occurrence of hyperemia with, and efficacy of, bimatoprost 0.01 % for patients in Korea previously treated for open-angle glaucoma (OAG; including normal tension glaucoma) or ocular hypertension (OHT).

METHODS:

In this multicenter, observational study (Asia Pacific Patterns from Early Access of Lumigan 0.01 % in Korea; APPEAL Korea), patients with unachieved target intraocular pressure (IOP) despite previous treatment received bimatoprost 0.01 % daily for 12 weeks. The primary endpoint was incidence of hyperemia and its severity, graded using the standard 5-point photographic scale and grouped as "none to mild" and "moderate to severe". Hyperemia shifts were reported. IOP and adverse events (AEs) were recorded.

RESULTS:

Of 800 patients (intent-to-treat/safety population), 248 were switched from previous treatment to bimatoprost 0.01 % monotherapy. Hyperemia shifts from baseline at weeks 6 and 12 were unchanged (84.8, 89.8 %), improved (4.4, 4.8 %), or worsened (10.8, 5.4 %), respectively. The shift was significant at week 6 (P < 0.0001). Hyperemia did not worsen significantly in patients previously receiving a prostaglandin analog or prostamide (PGA/PSD). Baseline mean IOP ± SD was 17.0 ± 5.7 mmHg, decreasing to 14.6 ± 3.8 mmHg (P < 0.0001) after 6 weeks, and to 14.7 ± 3.6 mmHg (P < 0.0001) after 12 weeks. Patients switched from PGA or PSD (excluding bimatoprost 0.03 %) to bimatoprost 0.01 % experienced significant IOP reductions from baseline. Treatment-related ocular AEs were reported by 37 patients, the most common being hyperemia (7.3 %).

CONCLUSIONS:

This subanalysis of the APPEAL Korea study supports use of bimatoprost 0.01 % for previously treated patients with OAG (including normal tension glaucoma) or OHT who did not reach target IOP or were intolerant of previous treatment.

• Authors: Michael Scott Kook, Susan Simonyi, Yong Ho Sohn, Chan Yun Kim, Ki Ho Park
• Journal: Japanese journal of ophthalmology (Jpn J Ophthalmol) Vol. 59 Issue 5 Pg. 325-34 (Sep 2015) ISSN: 1613-2246 [Electronic] Japan
• PMID: 26202440 (Publication Type: Journal Article, Multicenter Study, Observational Study)

Chemical References

• Antihypertensive Agents
• Ophthalmic Solutions
• Bimatoprost

Topics

• Administration, Topical
• Aged
• Antihypertensive Agents (therapeutic use)
• Asian People
• Bimatoprost (therapeutic use)
• Conjunctiva (blood supply)
• Drug Substitution
• Female
• Glaucoma, Open-Angle (diagnosis, drug therapy, physiopathology)
• Humans
• Hyperemia (physiopathology)
• Intraocular Pressure (drug effects)
• Male
• Middle Aged
• Ocular Hypertension (diagnosis, drug therapy, physiopathology)
• Ophthalmic Solutions
• Republic of Korea
• Single-Blind Method
• Tonometry, Ocular