Abstract | BACKGROUND AND OBJECTIVE: METHODS: RESULTS: CONCLUSIONS: HCV replication decreasing the NAD(+)/ NADH ratio may downregulate the activity and expression of SIRT1, then change the expression profile of glucose metabolism-related genes, thereby causing glucose metabolism disorders of hepatocytes and promoting HCV replication. Treatment with SIRT1 activator improves glucose metabolic disorders and inhibits HCV replication, suggesting that restoration of SIRT1 activity may be a promising new therapeutic approach for CHC patients with IR.
|
Authors | Jian-Wu Yu, Li-Jie Sun, Yong-Hua Zhao, Peng Kang, Bing-Zhu Yan |
Journal | Hepatology international
(Hepatol Int)
Vol. 7
Issue 2
Pg. 524-32
(Jun 2013)
ISSN: 1936-0533 [Print] United States |
PMID | 26201784
(Publication Type: Journal Article)
|