In Cell Interactome of Oleocanthal, an Extra Virgin Olive Oil Bioactive Component.

Abstract

A copper-(I)-catalyzed variation of the Huisgen 1,3-dipolar cycloaddition has been applied to lead the in living-cell mass-spectrometry based identification of protein targets of oleocanthal, a natural metabolite daily ingested by millions of people. Chemical proteomics revealed heat-shock proteins, HSP70 and HSP90, as main oleocanthal interactors in living systems. These two proteins are involved in cancer development and, thus, our findings could have important outcomes for a deep evaluation of the bio-pharmacological significance of oleocanthal.

• Authors: Chiara Cassiano, Agostino Casapullo, Alessandra Tosco, Maria Chiara Monti, Raffaele Riccio
• Journal: Natural product communications (Nat Prod Commun) Vol. 10 Issue 6 Pg. 1013-6 (Jun 2015) ISSN: 1934-578X [Print] United States
• PMID: 26197539 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aldehydes
• Cyclopentane Monoterpenes
• HSP70 Heat-Shock Proteins
• HSP90 Heat-Shock Proteins
• Olive Oil
• Phenols
• Plant Oils
• oleocanthal

Topics

• Aldehydes (chemistry, metabolism)
• Cyclopentane Monoterpenes
• HSP70 Heat-Shock Proteins (chemistry, metabolism)
• HSP90 Heat-Shock Proteins (chemistry, metabolism)
• Humans
• Mass Spectrometry
• Olive Oil
• Phenols (chemistry, metabolism)
• Plant Oils (chemistry, metabolism)
• Protein Binding
• Proteomics