Rapidly light-activated surgical protein glue inspired by mussel adhesion and insect structural crosslinking.

Abstract

Currently approved surgical tissue glues do not satisfy the requirements for ideal bioadhesives due to limited adhesion in wet conditions and severe cytotoxicity. Herein, we report a new light-activated, mussel protein-based bioadhesive (LAMBA) inspired by mussel adhesion and insect dityrosine crosslinking chemistry. LAMBA exhibited substantially stronger bulk wet tissue adhesion than commercially available fibrin glue and good biocompatibility in both in vitro and in vivo studies. Besides, the easily tunable, light-activated crosslinking enabled an effective on-demand wound closure and facilitated wound healing. Based on these outstanding properties, LAMBA holds great potential as an ideal surgical tissue glue for diverse medical applications, including sutureless wound closures of skin and internal organs.

• Authors: Eun Young Jeon, Byeong Hee Hwang, Yun Jung Yang, Bum Jin Kim, Bong-Hyuk Choi, Gyu Yong Jung, Hyung Joon Cha
• Journal: Biomaterials (Biomaterials) Vol. 67 Pg. 11-9 (Oct 2015) ISSN: 1878-5905 [Electronic] Netherlands
• PMID: 26197411 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Cyanoacrylates
• Fibrin Tissue Adhesive
• Proteins
• Recombinant Proteins
• Tissue Adhesives
• adhesive protein, mussel
• Hydrogel, Polyethylene Glycol Dimethacrylate
• Tyrosine
• dityrosine

Topics

• Animals
• Bivalvia (chemistry)
• Cell Death (drug effects)
• Cell Line
• Cyanoacrylates (pharmacology)
• Fibrin Tissue Adhesive (pharmacology)
• Humans
• Hydrogel, Polyethylene Glycol Dimethacrylate (pharmacology)
• Insecta (chemistry)
• Light
• Proteins (pharmacology)
• Rats, Sprague-Dawley
• Recombinant Proteins (pharmacology)
• Skin (drug effects, pathology)
• Sus scrofa
• Sutures
• Tissue Adhesives (pharmacology)
• Tyrosine (analogs & derivatives, chemistry)
• Wound Healing (drug effects)