[A prospective study of serum fibroblast growth factor 21 changes in nonalcoholic fatty liver patients].

Abstract

OBJECTIVE:

To investigate the prospective association of fibroblast growth factor 21 (FGF-21) with NAFLD development in a 5-year prospective study involving a population-based cohort comprising 352 Chinese subjects.

METHODS:

The clinical data of subjects were recorded, serum FGF-21 levels at baseline and follow-up were measured using an enzyme-linked immunosorbent assay,whether FGF-21 was independent predictor of NAFLD development were identified using logistic regressions. Chi-square test, non-parametric test and logistic regression analysis were used in statistical analyses.

RESULTS:

(1) Serum FGF-21 levels of NAFLD group was significantly higher than that of non-NAFLD group (318.34(169.64,520.77)pg/ml vs 197.22 (121.57, 318.76) pg/ml, Probability value less than 0.05). (2)At follow-up,significant increase of FGF-21 level was observed in those subjects who developed NAFLD (399.4 (253.9,754.2) pg/ml vs 318.34(169.64, 520.77)pg/ml, Probability value less than 0.05), but in non-NAFLD group, there was no significant difference of FGF-21 level between baseline and follow-up. (3) BMI, TC, HOMA-IR and FGF-21 were independent predictors of NAFLD through logistic regressions.

CONCLUSION:

High FGF-21 levels was independent predictor of NAFLD, it may be useful for early diagnosis and intervention of NAFLD.

• Authors: Leilei Zhan, Hongmei Zhou, Rongguo Chen
• Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (Zhonghua Gan Zang Bing Za Zhi) Vol. 23 Issue 5 Pg. 350-3 (May 2015) ISSN: 1007-3418 [Print] China
• PMID: 26192240 (Publication Type: Journal Article)

Chemical References

• Interleukins
• interleukin-21

Topics

• Enzyme-Linked Immunosorbent Assay
• Follow-Up Studies
• Humans
• Interleukins
• Logistic Models
• Non-alcoholic Fatty Liver Disease
• Prospective Studies