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Association between urinary levels of bisphenol A and its monochlorinated derivative and obesity.

Abstract
Population-based studies suggest the association between exposures to bisphenol A (BPA) and obesity. However, no human studies are available that link exposures to chlorinated derivatives of BPA with obesity biomarkers. The objective of this exploratory post hoc analysis of our cross-sectional study's dataset was to evaluate the association between urinary levels of BPA and monochlorinated BPA (mono-ClBPA) with body mass index (BMI) in a random sample of 223 adults (≥18 years) from the general population in Cyprus. Univariate analysis and multiple logistic regressions were performed for descriptive statistics and estimating odds ratio (OR) of above normal BMI, respectively. We observed a relatively weak positive association between urinary mono-ClBPA and BMI, such as (i) 76 ng g(-1) in participants with above normal BMI (≥25 kg m(-2)) versus 55 ng g(-1) in those with normal BMI (<25 kg m(-2)) (P for mean difference = 0.053) and (ii) higher percentage of participants with above normal BMI in the high urinary mono-ClBPA tertile (63% in tertile 3 and 57% in tertile 2 versus 50% in tertile 1, P for trend = 0.056). Similar tests of association between urinary BPA and BMI showed null outcome. A dichotomously-classified group analysis showed an increased odds ratio (OR) for higher BMI in the group with high creatinine-adjusted urinary levels of BPA and mono-ClBPA when compared with the participants group with low levels for both compounds [logistic model adjusted for gender and health status as potential confounders; adjusted OR (95% CI): 2.34 (1.10, 5.10), P = 0.027]. Measurements of both BPA and its trace chlorinated derivative in human matrices may be warranted for a comprehensive exposure assessment towards improving our understanding of their obesogenic effects.
AuthorsSyam S Andra, Konstantinos C Makris
JournalJournal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering (J Environ Sci Health A Tox Hazard Subst Environ Eng) Vol. 50 Issue 11 Pg. 1169-79 ( 2015) ISSN: 1532-4117 [Electronic] England
PMID26191991 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Benzhydryl Compounds
  • Biomarkers
  • Phenols
  • bisphenol A
Topics
  • Adult
  • Aged
  • Benzhydryl Compounds (adverse effects, urine)
  • Biomarkers (urine)
  • Body Mass Index
  • Cross-Sectional Studies
  • Cyprus
  • Environmental Exposure (adverse effects)
  • Female
  • Health Status
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Obesity (chemically induced, urine)
  • Odds Ratio
  • Phenols (adverse effects, urine)

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