The study of
carcinogenesis is most advanced in
bladder cancer through the study of what is called
aniline bladder cancer.
Bladder cancer has also played a key role in introducing the concept of 'occupational'
cancer. Industrial Safety and Health Law defines various chemical substances as
carcinogens of 'occupational'
cancer, many of which are related to the urinary tract
tumor, including
benzidine,
beta-naphthylamine,
alpha-naphthylamine,
4-aminodiphenyl, 4-netrodiphenyl,
auramine, magenta, orthotolidine,
dianisidine, dichlorobenzidine and paradimethylaminoazobenzene. When a patient has been exposed to any of these substances, a diagnosis of 'occupational'
cancer is made after consultation in the Central Labor Standards Council. Few
bladder cancer patients are acknowledged as victims of 'occupational'
cancer. In most cases the cause of
bladder cancer remains unknown. However, cases of
cancer caused by chemical substances are increasing, and many other chemical substances are probably carcinogenic. Although regulations on 'occupational'
cancer have been completed, there are many cases of inconvenience in practice. In this report I investigated into such clinical problems and also studied the above-mentioned
carcinogens.