[Dermatological manifestations of monoclonal gammopathies: contribution of cutaneous histopathology].

Abstract

Skin manifestations associated with monoclonal gammapathy are common and can present with various clinical and pathological aspects. They can be the first events leading to the diagnosis of monoclonal gammapathy. They may be present either as specific lesions, including lymphoplasmacytic or pure plasma cell neoplastic infiltrates and monoclonal immunoglobulin deposits, or as non-specific dermatitis, such as leukocytoclastic vasculitis, neutrophilic dermatoses, mucinoses or xanthomatosis, giving little clues for the diagnosis of the underlying disease.

• Authors: Caroline Lacoste, Saskia Ingen-Housz-Oro, Nicolas Ortonne
• Journal: Annales de pathologie (Ann Pathol) Vol. 35 Issue 4 Pg. 281-93 (Aug 2015) ISSN: 0242-6498 [Print] France
• Vernacular Title: Manifestations dermatologiques des gammapathies monoclonales : apport de l'histopathologie cutanée.
• PMID: 26188671 (Publication Type: English Abstract, Journal Article, Review)
• Copyright: Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Chemical References

• Amyloid
• Immunoglobulin M
• Paraproteins

Topics

• Amyloid (analysis)
• Humans
• Immunoglobulin M (analysis)
• Mucinoses (etiology, pathology)
• Paraproteinemias (complications, pathology)
• Paraproteins (analysis)
• Plasma Cells (pathology)
• Skin (chemistry, pathology)
• Skin Diseases (etiology, pathology)
• Skin Diseases, Vesiculobullous
• Vasculitis, Leukocytoclastic, Cutaneous (etiology, pathology)
• Xanthomatosis (etiology, pathology)