Creatine-kinase-BB after severe head-injury as an index of prognosis in relation to nature of trauma and patients age.

Abstract

Creatine-Kinase-BB (CK-BB) is a brain specific enzyme, with a prognostic value for the patient's outcome after head-injury. We have investigated 76 brain injured patients and attempted to show a correlation of the concentrations of CK-BB and the Glasgow-Outcome-Scale (GOS). Patients with a CK-BB concentration of more than 50 ng/ml died. Patients, who had a CK-BB concentration less than 25 ng/ml showed only minimal neurological deficits. Intracerebral contusions and acute subdural haematomas showed the highest CK-BB concentration, indicating a high degree of braintissue-damage. CK-BB seems to have no correlation with the age of patients. Normalisation of elevated CK-BB levels do not correlate with recovery from neurological deficit.

• Authors: A Niedeggen, D Adelt, R Berndt, T Hopf
• Journal: Acta neurochirurgica (Acta Neurochir (Wien)) Vol. 101 Issue 3-4 Pg. 117-20 ( 1989) ISSN: 0001-6268 [Print] Austria
• PMID: 2618815 (Publication Type: Journal Article)

Chemical References

• Creatine Kinase

Topics

• Adolescent
• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Brain Injuries (complications, enzymology, physiopathology)
• Creatine Kinase (metabolism)
• Female
• Hematoma, Epidural, Cranial (complications, enzymology, physiopathology)
• Hematoma, Subdural (complications, enzymology, physiopathology)
• Humans
• Male
• Middle Aged