[Immunosuppresive effects of wilfortrine and euonine].

Abstract

Wifortrine and Euonine isolated from Tripterygium wilfordii Hook. f. Wilfortrine and euonine (40.80 mg/(kg.d) x 4d ip) showed marked depressant effects on humoral mediated immunity using the hemolysin reaction as indices. Wilfortrine (160 mg/kg.d x 9d ip) exhibited a depressant effect on graft vs host reaction (GVHR), but wilfortrine (80 mg/(kg.d) x 9d ip) showed no definite effect. Euonine (80 mg/(kg.d) x 10d ip) showed marked suppressant effects on DNCB induced delayed hypersensitivity reaction on skin in mice. Wilfortrine and Euonine (80 mg/(kg.d) x 4d ip) significantly decreased the clearance rate of charcoal particles and the weights of spleen and thymus.

• Authors: Y L Zheng, Y Xu, J F Lin
• Journal: Yao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 24 Issue 8 Pg. 568-72 ( 1989) ISSN: 0513-4870 [Print] China
• PMID: 2618700 (Publication Type: English Abstract, Journal Article)

Chemical References

• Alkaloids
• Hemolysin Proteins
• Charcoal
• wilfortrine
• euonine

Topics

• Alkaloids (pharmacology)
• Animals
• Charcoal (pharmacokinetics)
• Female
• Graft vs Host Reaction (drug effects)
• Hemolysin Proteins (biosynthesis)
• Hypersensitivity, Delayed
• Male
• Metabolic Clearance Rate (drug effects)
• Mice
• Mice, Inbred C57BL
• Mice, Inbred ICR