Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins.

Abstract

Ribosome-inactivating proteins (RIPs) belong to a family of enzymes that attack eukaryotic ribosomes and potently inhibit cellular protein synthesis. RIPs possess several biomedical properties, including anti-viral and anti-tumor activities. Multiple RIPs are known to inhibit tumor cell proliferation through inducing apoptosis in a variety of cancers, such as breast cancer, leukemia/lymphoma, and hepatoma. This review focuses on the anti-tumor activities of RIPs and their apoptotic effects through three closely related pathways: mitochondrial, death receptor, and endoplasmic reticulum pathways.

• Authors: Meiqi Zeng, Manyin Zheng, Desheng Lu, Jun Wang, Wenqi Jiang, Ou Sha
• Journal: Chinese journal of cancer (Chin J Cancer) Vol. 34 Issue 8 Pg. 325-34 (Jul 17 2015) ISSN: 1000-467X [Print] England
• PMID: 26184404 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antineoplastic Agents
• Plant Proteins
• Receptors, Death Domain
• Ribosome Inactivating Proteins

Topics

• Animals
• Antineoplastic Agents
• Apoptosis
• Endoplasmic Reticulum
• Humans
• Mitochondria
• Plant Proteins
• Receptors, Death Domain
• Ribosome Inactivating Proteins
• Ribosomes