High-mobility group A2 overexpression is an unfavorable prognostic biomarker for nasopharyngeal carcinoma patients.

Abstract	Our previous study showed that knockdown of high-mobility group A2 (HMGA2) could suppress nasopharyngeal carcinoma (NPC) cell migration, invasion, and epithelial-mesenchymal transition (EMT) process, and HMGA2 is a direct functional target of let-7 to regulate NPC cell migration, invasion, and EMT process. However, little is known about the clinical and prognostic significance of HMGA2 protein in NPC patients. The purpose of this study is to identify the clinical and prognostic roles of HMGA2 in NPC patients. We initially analyzed the microarray data and verified mRNA and protein levels of HMGA2 in NPC tissues. Immunohistochemical staining for HMGA2 protein was performed in 116 NPC patients. The associations between HMGA2 protein expression and clinicopathologic features and its prognostic significance were analyzed. In our results, we found mRNA and protein expressions of HMGA2 were upregulated in NPC tissues and cell lines. In 116 NPC tissue samples, we observed that HMGA2 protein overexpression was associated with clinical stage, lymph node metastasis, and distant metastasis. Moreover, NPC patients with high levels of HMGA2 protein expression had shorter overall survival in comparison to patients with low levels of HMGA2 protein. In multivariate analysis, HMGA2 protein overexpression was an unfavorable prognostic factor for NPC patients. In conclusion, HMGA2 is an important biomarker to predicting NPC patient's survival time.
Authors	Zhuoxing Liu, Kunpeng Wu, Zhixiong Yang, Aibing Wu
Journal	Molecular and cellular biochemistry (Mol Cell Biochem) Vol. 409 Issue 1-2 Pg. 155-62 (Nov 2015) ISSN: 1573-4919 [Electronic] Netherlands
PMID	26183485 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Biomarkers, Tumor HMGA2 Protein RNA, Messenger
Topics	Adult Aged Aged, 80 and over Biomarkers, Tumor (metabolism) Carcinoma Cell Line, Tumor Epithelial-Mesenchymal Transition (genetics) Female Gene Expression Regulation, Neoplastic HMGA2 Protein (biosynthesis, genetics) Humans Lymphatic Metastasis (genetics, pathology) Male Middle Aged Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms (mortality, pathology) Prognosis RNA, Messenger (biosynthesis) Up-Regulation Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!