A Novel Class of Emerging Anticancer Compounds: Oxyprenylated Secondary Metabolites from Plants and Fungi.

Abstract

O-Prenyl secondary metabolites (3,3-dimethylallyl, geranyl-, farnesyl- and related biosynthetic derivatives) represent a class of rarely occurring natural products. In the last two decades such compounds have been found to exert promising and effective pharmacological activities, mainly in terms of anti-cancer properties. To date about 350 oxyprenylated secondary metabolites, the most part of which having a phenylpropanoid or a polyketide core, have been extracted from plants mainly belonging to the Rutaceae, Apiaceae, and Fabaceae families, and from fungi and bacteria. The aim of this comprehensive review is to make a survey of the in so far reported literature citations about O-prenyl secondary metabolites exhibiting in vitro and in vivo anti-cancer properties from phytochemical and pharmacological point of views.

• Authors: Salvatore Genovese, Serena Fiorito, Francesco Epifano, Vito Alessandro Taddeo
• Journal: Current medicinal chemistry (Curr Med Chem) Vol. 22 Issue 30 Pg. 3426-33 ( 2015) ISSN: 1875-533X [Electronic] United Arab Emirates
• PMID: 26180000 (Publication Type: Journal Article, Review)

Chemical References

• Biological Products
• Chalcones
• Coumarins
• Plant Extracts
• xinjiachalcone A
• aurapten

Topics

• Biological Products (chemistry, pharmacology)
• Cell Proliferation (drug effects)
• Chalcones (chemistry, pharmacology)
• Coumarins (chemistry, pharmacology)
• Fungi (chemistry, metabolism)
• Humans
• Molecular Structure
• Neoplasms (drug therapy)
• Oxidation-Reduction
• Plant Extracts (chemistry, pharmacology)
• Prenylation