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Anti-centromere antibody-positive Sjögren's syndrome: A distinct clinical subgroup?

AbstractAIM:
To investigate whether patients with Sjögren's syndrome (SS) can be distinguished based on the positivity of anti-centromere antibody (ACA), and if so, whether the subgroups differ in their clinical and laboratory features.
METHODS:
Eleven patients with ACA-positive and 71 patients ACA-negative SS were examined. All patients had minor salivary gland biopsy; sociodemographic data, glandular and extraglandular manifestations, and laboratory findings, including autoantibodies, complement and immunoglobulin levels, were analyzed. European League Against Rheumatism SS disease activity index (ESSDAI) and SS disease damage index (SSDDI) were also measured.
RESULTS:
The prevalence of ACA among SS patients was 13.4%. ACA-positive SS patients had a higher prevalence of Raynaud's phenomenon, sclerodactyly and autoimmune thyroiditis and a lower prevalence of anti-SSA/Ro and anti-SSB/La antibodies compared to ACA-negative patients. Disease activity was higher in ACA-positive patients than in ACA-negative patients, but the damage index did not differ between the two groups. None of the patients who originally had ACA evolved to having full-blown systemic sclerosis.
CONCLUSION:
Patients with SS who have ACA differ from classic SS patients in several clinical and laboratory parameters. ACA should be considered one of the pathogenically relevant autoantibodies for SS.
AuthorsKyung-Eun Lee, Ji-Hyoun Kang, Jeong-Won Lee, Lihui Wen, Dong-Jin Park, Tae-Jong Kim, Yong-Wook Park, Shin-Seok Lee
JournalInternational journal of rheumatic diseases (Int J Rheum Dis) Vol. 18 Issue 7 Pg. 776-82 (Sep 2015) ISSN: 1756-185X [Electronic] England
PMID26179502 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2015 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.
Chemical References
  • Antibodies, Antinuclear
  • Biomarkers
  • anticentromere antibody
Topics
  • Adult
  • Antibodies, Antinuclear (analysis)
  • Biomarkers (blood)
  • Biopsy
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prevalence
  • Prognosis
  • Republic of Korea (epidemiology)
  • Retrospective Studies
  • Salivary Glands (immunology, pathology)
  • Severity of Illness Index
  • Sjogren's Syndrome (blood, classification, diagnosis, epidemiology, immunology)

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