[Properties of monoamine oxidase in the brain of mongolian gerbils during cerebral ischemia].

Abstract

Properties of monoamine oxidase (MAO) were investigated in mongolian gerbils brain mitochondria isolated from cerebral cortex, striatum and hippocampus during cerebral ischemia. 5 min of ischemia caused inhibition of MAO activity (kynuramine as a substrate), alterations in substrate specificity and in kinetic curves form deflexion from hyperbolic type in all the brain structures investigated. Alterations in properties of MAO were observed in hippocampus already after I min of ischemia.

• Authors: I A Goroshinskaia, T Stoianovich, D V Michich, B B Mrshulia
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1989 Sep-Oct Vol. 35 Issue 5 Pg. 112-5 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Svoĭstva monoaminoksidazy v mozge mongol'skikh peschanok pri tserebral'noĭ ishemii.
• PMID: 2617926 (Publication Type: English Abstract, Journal Article)

Chemical References

• Monoamine Oxidase Inhibitors
• Monoamine Oxidase

Topics

• Animals
• Brain (enzymology)
• Brain Ischemia (enzymology)
• Deamination
• Gerbillinae
• Kinetics
• Monoamine Oxidase (metabolism)
• Monoamine Oxidase Inhibitors (metabolism)
• Substrate Specificity