Abstract | PURPOSE: MATERIALS AND METHODS: Between January 2002 and August 2012, orchiectomy specimens from 31 postpubertal patients (aged 12 or over) with cryptorchid testis were reviewed. The specimens were evaluated for ITGCN using immunohistochemical stains of placental-like alkaline phosphatase and Oct 3/4 with routine hematoxylin- eosin stain. Additionally, the degree of spermatogenesis was assessed using the Johnsen score. RESULTS: Mean age was 34 years (range, 17 to 74 years) at surgery. All patients were diagnosed as unilateral cryptorchidism. One patient (3.2%) of 20-year-old had ITGCN in surgical specimen with all positive markers. Histological assessment of spermatogenesis showed that mean Johnsen score was 3.42 (range, 1 to 9). Majority of patients (27 of 31) presented impaired spermatogenesis with low Johnsen score lesser than 5. CONCLUSIONS: Considering the risk of malignancy and low spermatogenesis, we should perform immunohistochemical stains and discuss preventative orchiectomy for the postpubertal cryptorchidism.
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Authors | Seung Hoon Ryang, Jae Hung Jung, Minseob Eom, Jae Mann Song, Hyun Chul Chung, Yunbyung Chae, Chang Min Lee, Kwang Jin Kim |
Journal | Korean journal of urology
(Korean J Urol)
Vol. 56
Issue 7
Pg. 515-8
(Jul 2015)
ISSN: 2005-6745 [Electronic] Korea (South) |
PMID | 26175870
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Isoenzymes
- germ-cell AP isoenzyme
- Alkaline Phosphatase
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Topics |
- Adolescent
- Adult
- Aged
- Alkaline Phosphatase
(metabolism)
- Biomarkers, Tumor
(metabolism)
- Carcinoma in Situ
(diagnosis, etiology, pathology)
- Cryptorchidism
(complications, surgery)
- Disease Progression
- Humans
- Infertility, Male
(etiology)
- Isoenzymes
(metabolism)
- Male
- Middle Aged
- Neoplasms, Germ Cell and Embryonal
(diagnosis, etiology, pathology, prevention & control)
- Orchiectomy
- Puberty
- Retrospective Studies
- Spermatogenesis
- Testicular Neoplasms
(diagnosis, etiology, pathology, prevention & control)
- Young Adult
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