Abstract |
The purpose of this review is to highlight the recent mechanistic developments elucidating the role of matrix metalloproteinases ( MMPs) in tumour invasion and metastasis. The ability of tumour cells to invade, migrate, and subsequently metastasize is a fundamental characteristic of cancer. Tumour invasion and metastasis are increasingly being characterized by the dynamic relationship between cancer cells and their microenvironment and developing a greater understanding of these basic pathological mechanisms is crucial. While MMPs have been strongly implicated in these processes as a result of extensive circumstantial evidence--for example, increased expression of individual MMPs in tumours and association of specific MMPs with prognosis--the underpinning mechanisms are only now being elucidated. Recent studies are now providing a mechanistic basis, highlighting and reinforcing the catalytic and non-catalytic roles of specific MMPs as key players in tumour invasion and metastasis.
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Authors | Gordon T Brown, Graeme I Murray |
Journal | The Journal of pathology
(J Pathol)
Vol. 237
Issue 3
Pg. 273-81
(Nov 2015)
ISSN: 1096-9896 [Electronic] England |
PMID | 26174849
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
Chemical References |
- Matrix Metalloproteinases
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Topics |
- Animals
- Cell Movement
- Epithelial-Mesenchymal Transition
- Extracellular Matrix
(metabolism)
- Humans
- Matrix Metalloproteinases
(metabolism)
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Neoplasms
(enzymology, pathology)
- Podosomes
(enzymology)
- Signal Transduction
- Tumor Microenvironment
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