Evaluation of intravenous regional perfusion with amphotericin B and dimethylsulfoxide to treat horses for pythiosis of a limb.

Abstract

BACKGROUND:

Treatment for horses with pythiosis of a limb is challenging. This study aims to evaluate the effects of administering amphotericin B in a 10 % solution of dimethylsulfoxide by intravenous regional limb perfusion (IRLP) to treat horses for cutaneous pythiosis of a limb.

RESULTS:

All 15 of the horses treated had complete resolutions of their lesion between 6 to 9 weeks after a single IRLP treatment. No complications were observed at the site of venipuncture for IRLP. Before initiation of treatment, there was anemia and marked leucocytosis which resolved following treatment. Serum biochemistry showed no significant changes.

CONCLUSIONS:

IRLP administration of amphotericin B in a 10 % DMSO solution was easily performed, relatively inexpensive and an effective treatment for treating horses for pythiosis of a limb and resolved the infection with no complications.

• Authors: Renata G S Dória, Mariana B Carvalho, Silvio H Freitas, Luciane M Laskoski, Edson M Colodel, Fábio S Mendonça, Marco A G Silva, Renan Grigoletto, Paulo Fantinato Neto
• Journal: BMC veterinary research (BMC Vet Res) Vol. 11 Pg. 152 (Jul 16 2015) ISSN: 1746-6148 [Electronic] England
• PMID: 26174778 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents
• Amphotericin B
• Dimethyl Sulfoxide

Topics

• Amphotericin B (administration & dosage, therapeutic use)
• Animals
• Anti-Infective Agents (administration & dosage, therapeutic use)
• Dimethyl Sulfoxide (administration & dosage, therapeutic use)
• Drug Therapy, Combination
• Female
• Forelimb (microbiology, pathology)
• Hindlimb (microbiology, pathology)
• Horse Diseases (drug therapy)
• Horses
• Injections, Intravenous
• Male
• Pythiosis (drug therapy)
• Pythium (isolation & purification)