Abstract | BACKGROUND:
Anorectal anomalies are atresias or stenoses of the anal canal and rectum with or without fistulous connections with the bladder, urethra, perineum, or vestibule. The aim of this study was to describe the epidemiology of anorectal anomalies, including associated anomalies, prevalence, and temporal trends. METHODS: RESULTS: There were 278 cases among 892,194 live births. Twenty (7.2%) cases occurred in twin pregnancies and 24 (8.7%) with chromosomal anomalies/genetic syndromes were excluded. There were 234 cases (total prevalence = 2.7, 95% confidence interval [CI]: 2.4, 3.1 per 10,000 live and stillbirths). There was no evidence of a trend in prevalence over time (Chi(2) test for trend: p = 0.789). There was a male predominance (70.9%). Of the 234 cases, 167 (71.4%) were live born, two (0.9%) were late miscarriages, seven (3.0%) were stillbirths, and 58 (24.8%) were terminations of pregnancy for fetal anomaly. There was no significant association with maternal age at delivery (p = 0.095). 7.2% of isolated cases (cases with no other congenital anomalies) were diagnosed prenatally. CONCLUSION: The prevalence of anorectal anomalies in this study is comparable to other case series. There was no evidence of a temporal increase in prevalence. We confirmed a male predominance of anorectal anomalies and no significant association with maternal age. Birth Defects Research (Part A) 103:597-602, 2015. © 2015 Wiley Periodicals, Inc.
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Authors | Alok S Godse, Kate E Best, Anne Lawson, Lucy Rosby, Judith Rankin |
Journal | Birth defects research. Part A, Clinical and molecular teratology
(Birth Defects Res A Clin Mol Teratol)
Vol. 103
Issue 7
Pg. 597-602
(Jul 2015)
ISSN: 1542-0760 [Electronic] United States |
PMID | 26173562
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 Wiley Periodicals, Inc. |
Topics |
- Anal Canal
(abnormalities)
- Congenital Abnormalities
(epidemiology)
- England
(epidemiology)
- Female
- Humans
- Infant, Newborn
- Male
- Prevalence
- Rectum
(abnormalities)
- Registries
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